q่r Vesicular glutamate uptake and release: a new model of modulation.
qาr Dr. Tetsufumi Ueda
@iProfessor and Senior Research Scientisj
@ University of Michigan, Mental Health Research Institute, USA
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@The vesicular glutamate uptake protein inhibitor IPF, when introduced into synaptosomes, caused a reduction in exocytotically released glutamate. A potent membrane-permeant vesicular glutamate inhibitor, when incubated with synaptosomes, lowered stored vesicular glutamate in the synaptosome and led to a decrease in exocytotically released glutamate. These observations indicate that the vesicular quantal size of glutamate can be varied, suggesting an alternative mode of modulation for glutamate synaptic transmission.
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